Tag: human lymphatic specification
Human Embryonic Lymphatic Progenitor Cell Origin and Early Lymphangiogenesis
During human embryogenesis, lymphatic progenitor cells emerge primarily from mesodermal tissues, with paraxial mesoderm serving as the principal source. By approximately week 6-7 of human gestation (equivalent to E12.5 in the comparative mouse model shown in the right side of the image), a significant milestone in lymphatic development occurs as initial lymphatic endothelial cells (LECs) begin sprouting from the cardinal vein and organizing into primitive lymphatic structures.
